Ethanaminium, 2-((3-(4-hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propenyl)o xy)-N,N,N-trimethyl-
Sinapine
CAS: 18696-26-9
Molecular Formula: [C16H24NO5]+.
Ethanaminium, 2-((3-(4-hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propenyl)o xy)-N,N,N-trimethyl- - Names and Identifiers
Ethanaminium, 2-((3-(4-hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propenyl)o xy)-N,N,N-trimethyl- - Physico-chemical Properties
| Molecular Formula | [C16H24NO5]+. |
| Molar Mass | 310.369 |
| Melting Point | 178℃ |
| Solubility | Soluble in methanol and water |
| Appearance | Powder |
| Storage Condition | 2-8℃ |
| In vitro study | Sinapine (6 or 60 μM; 1 h) counteracts H 2 O 2 and antimycin A-induced mitochondrial oxidative stress in cardiomyocytes. Sinapine (10-200 μM; 24 h) inhibits the proliferation of Caco-2 cells in a dose-dependent manner, and has relatively low toxicity. Sinapine (10-200 μM; 24 h) promotes doxorubicin accumulation in Caco-2 cell by inducing P-glycoprotein (P-gp) decrease. Sinapine (10-200 μM; 24 h) significantly reduces phosphorylation of FRS2α, ERK1/2. |
| In vivo study | Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota. |
Ethanaminium, 2-((3-(4-hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propenyl)o xy)-N,N,N-trimethyl- - Reference
| Reference Show more | 1. [IF=7.514] Zuoyong Zhang et al."Effect of pH regulation on the components and functional properties of proteins isolated from cold-pressed rapeseed meal through alkaline extraction and acid precipitation."Food Chem. 2020 Oct;327:126998 |
Ethanaminium, 2-((3-(4-hydroxy-3,5-dimethoxyphenyl)-1-oxo-2-propenyl)o xy)-N,N,N-trimethyl- - Reference Information
| biological activity | Sinapine is an alkaloid isolated from the seeds of Cruciferae species, which has antioxidant, anti-tumor and radioprotective effects. Sinapine inhibited the proliferation of P-glycoprotein cells by down-regulating Caco-2. |
| Target | Value |
| Use | for content determination/identification/pharmacological experiments |
Last Update：2024-04-09 19:05:16
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Spot supply
Product Name: Sinapine Visit Supplier Webpage Request for quotationCAS: 18696-26-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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